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environment or a more susceptible population? Thorax 1994; 49: 171–174. 9. Holgate ST. The epidemic of allergy and asthma. Nature 1999; 402 (6760 Suppl): B2–B4. 10. Holt PG, Macaubas C, Stumbles PA, Sly PD. The role of allergy in the development of asthma [review]. Nature 1999; 402: B12–B17. 11. Strachan DP, Harkins LS, Johnson ID, Anderson HR. Childhood antecedents of allergic sensitization in young British adults. J Allergy Clin Immunol 1997; 99: 6–12. 12. Ishizaka K, Ishizaka T, Hornbrook MM. Physico-chemical properties of human reaginic antibody. IV. Presence of a unique immunoglobulin as a carrier of reaginic activity. J Immunol 1966; 97: 75–85. 13. Prescott SL, Macaubas C, Smallacombe T, Holt BJ, Sly PD, Loh R, Holt PG. Reciprocal age-related patterns of allergen-specific T-cell immunity in normal vs. atopic infants. Clin Exp Allergy 1998; 28: 39–44. 14. Miles EA, Warner JA, Jones AC, Colwell BM, Bryant TN, Warner JO. Peripheral blood mononuclear cell proliferative responses in the first year of life in babies born to allergic parents. Clin Exp Allergy 1996; 26: 780–788. 15. Platts-Mills TAE, Woodfolk JA. Cord blood proliferative responses to inhaled allergens: is there a phenomenon? [editorial]. J Allergy Clin Immunol 2000; 106: 441–443. 16. Rowntree S, Cogswell JJ, Platts-Mills TAE, Mitchell EB. Development of IgE and IgG antibodies to food and inhalant allergens in children at risk of allergic disease. Arch Dis Child 1985; 60: 727–735. 17. Sporik R, Squillace SP, Ingram JM, Rakes G, Honsinger RW, Platts-Mills TAE. Mite, cat and cockroach exposure, allergen sensitization, and asthma in children: a case-control study of three schools. Thorax 1999; 54: 675–680. 18. Hasselmar B, Aberg N, Aberg B, Eriksson B, Bjorksten B. Does early exposure to cat or dog protect against later allergy development? Clin Exp Allergy 1999; 29: 611–617. 19. Svane C, Jarvis D, Chinn S, Burney P. Childhood environment and adult atopy: results from the European Community Respiratory Health Survey. J Allergy Clin Immunol 1999; 103: 415–420. 20. Platts-Mills T, Vaughan J, Squillace S, Woodfolk J, Sporik R. Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. The Lancet 2001; 357: 752–756. 21. Fredburg JJ, Inouye DS, Mijailovich SM, Butler JP. Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm. Am J Resp Crit Care Med 1999; 159: 959–967. 22. Skloot G, Permutt S, Togias A. Airway hyperresponsiveness in asthma. J Clin Invest 1995; 96: 2393–2403. 23. Luder E, Melnik TA, DiMaio M. Association of being overweight with greater asthma symptoms in inner city black and Hispanic children. J Peds 1998; 132: 699–703. 24. Camargo CA, Weiss ST, Zhang S, Willett WC, Spetzer FE. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med 1999; 159: 2582. 25. Platts-Mills TAE, Woodfolk JA, Chapman MD, Heymann PW. Changing concepts of allergic disease: the attempt to keep up with real changes in lifestyles [review]. J Allergy Clin Immunol 1996; 98: S297–S306.

Atopic dermatitis: a paradigmatic allergic skin disease