English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Despite the association of genetic factors with falls, balance, and lower extremity functioning, interaction of the angiotensin-converting enzyme ( ACE ) gene insertion/deletion (I/D) polymorphism with fear of falling (FOF) in relation to stepping performance has, to the best of our knowledge, not been investigated in older adults. The purpose of this study was to examine the interaction effects of the  ACE  I/D polymorphism with FOF in relation to stepping performance in older adults. Eighty-eight community-dwelling adults 60 years or older participated in a cross-sectional observational study. Participants completed tests of rapid and distance stepping, and self-reported FOF (yes/no). Participants provided saliva for  ACE  genotyping. General linear models evaluated  ACE  genotype × FOF interaction effects in relation to stepping performance. The α level was set at 0.05. The  ACE  I/D polymorphism exhibited significant interaction effects ( p  for interactions 0.002 ≤  p  ≤ .04) with FOF in relation to stepping speed. Relationships between FOF and stepping speed varied among  ACE  genotypes. The insertion/insertion (II) genotype was significantly associated ( p  = .01) with slow stepping in individuals with, but not without FOF ( p  &gt; .05). Variation in relationships between FOF and stepping speed among  ACE  genotypes suggests a role for the  ACE  I/D polymorphism in modifying relationships between FOF and stepping speed in older adults. The association of the  ACE  II genotype with slow stepping performance in individuals with, but not without FOF, suggests that older adults with the  ACE  II genotype and FOF may be at increased risk for poor stepping performance and associated functional declines.

physiotherapy theory and practice

The angiotensin-converting enzyme gene insertion/deletion polymorphism interacts with fear of falling in relation to stepping speed in community-dwelling older adults