English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Many genes and miRNAs have been shown to be associated with the pathogenesis of endometriosis.  TP63  (p63) is implicated in lineage specification, proliferative potential, differentiation, cell death and survival. The  ABL1  proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase implicated in cell differentiation, cell division, and cell adhesion. Moreover, hsa-miR-203a-3p was reported to play pivotal roles in tumor progression by targeting multiple genes, including  ABL1  and  TP63 . The aim of this study was to investigate the expression of  ABL1 ,  TP63 , and miR-203a-3p in endometriosis. This study included 30 women with endometriosis (stage III:  n  = 12 and stage IV:  n  = 18) and 30 age-matched controls. Total RNA extraction and cDNA synthesis were performed, and a quantitative polymerase chain reaction technique was used to determine the expression of miR-203a-3p,  TP63 , and  ABL1 . TP63  and  ABL1  were significantly overexpressed in stages III and IV endometriosis as compared to controls ( p  &lt; .0001). Moreover, overexpression of  ABL1  and  TP63  was observed in stage IV compared to stage III ( p  = .0006 and  p  = .0002, respectively). Furthermore, significant increase miR-203a-3p expression has been seen in stage IV endometriosis compared to controls ( p  = .006). The expression of miR-203a-3p in stage III was not significant compared to stage IV and control ( p  = .33 and  p  = .43, respectively). It is concluded that miR-203a-3p,  ABL1  and  TP63  gene expression is altered in the endometrium of patients with endometriosis. It is also suggested that miR-203a-3p,  ABL1 , and  TP63  might be candidate factors for the pathogenesis of endometriosis and suggesting its therapeutic potential in endometriosis.

miR-203a-3p, ABL1 and TP63 gene expression is altered in the endometrium of women with endometriosis