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To understand the pathogenesis in rat corneal endothelial cells (RCECs) induced by murine cytomegalovirus infection  in vitro and in vivo . In vitro , cultured RCECs were infected with murine cytomegalovirus strain K181-eGFP (MCMV-eGFP).  In vivo , experimental rats received intracameral injection of MCMV-eGFP. Replicating viruses and morphology change of RCECs  in vivo  were evaluated at several time points. In vitro , RCECs became necrosis at 6hpi. MCMV-eGFP began replicating at 12hpi.  In vivo , the inflammatory reactions appeared at 12hpi, peaked at 72hpi and gradually subsided. Replicating MCMV-eGFP appeared in RCECs  in vivo  from 24hpi to 72hpi. RCECs enlarged after 12hpi and capsids in the nuclei were visible at 72hpi. A monocyte was found on a corneal endothelium at 120hpi. RCECs were sensitive to MCMV  in vitro . Replication of MCMV-eGFP  in vivo  began at 24hpi and ended after 72hpi, later than the inflammatory reactions.

Pathogenic Effects and Pathogenesis Processes in Vitro & in Vivo in Murine Cytomegalovirus Infected Rat Corneal Endothelial Cells