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Surgeons may use laboratory tests, including erythrocyte sedimentation rate, C-reactive protein (CRP), and white blood cell count, as well as joint aspirations to diagnose prosthetic joint infections. There is a paucity of literature correlating preoperative inflammatory markers with risk of infection in the setting of salvage total hip arthroplasty (THA). This retrospective case analysis included patients who underwent a THA salvage procedure a minimum of 3 months after a failed fixation of a proximal femur or acetabulum, with a goal of assessing the utility of inflammatory markers as a screening tool in preoperative evaluation of salvage THA. Eighty-five patients met inclusion criteria. Thirteen patients were diagnosed with an infection preoperatively or intraoperatively during salvage THA. An elevated preoperative CRP level was a significant marker for infection. A CRP of 7.1 produced 80% sensitivity, 88% specificity, and a receiver operating characteristic curve of 0.840. There was a high rate of perioperative complications (17.6%) in salvage THA regardless of the presence of infection. In conclusion, CRP levels are useful in the preoperative evaluation for periprosthetic joint infection before salvage THA.

Role of inflammatory markers in the preoperative evaluation of patients undergoing salvage total hip arthroplasty