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Biofilm production facilitates microbial colonization of wounds and catheters.  Acinetobacter baumannii  produces high levels of biofilm and causes difficult-to-treat nosocomial infections.  Candida albicans  is another strong biofilm producer which may facilitate  A. baumannii  adhesion by providing hyphae-mediated OmpA-binding sites. Here we tested the potential of 2′-hydroxychalcones to inhibit dual-species biofilm production of  A. baumannii  and  Candida  spp., and further predicted the mechanism of structure-related difference in activity. The results suggest that 2′-hydroxychalcones exhibit potent activity against  Candida  spp./ A. baumannii  dual-species biofilm production. Particularly active was trifluoromethyl-substituted derivative (p-CF 3 ), which decreased  C. albicans / A. baumannii  biomass produced on vein-indwelling parts of the central venous catheterization set by up to 99%. Further, higher OmpA-binding affinity was also calculated for p-CF 3 , which together with demonstrated significant  ompA -downregulating activity, suggests that superior antibiofilm activity of this chalcone against the tested dual-species community of  A. baumannii  is mediated through the OmpA.

biofouling

Targeting outer membrane protein A (OmpA) – inhibitory effect of 2′-hydroxychalcone derivatives on  Acinetobacter baumannii  and  Candida albicans  dual-species biofilm formation