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Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous disorder and Sluggish Cognitive Tempo (SCT) might be a second inattention disorder that might be even affected by different attention pathways. SCT is characterized by daydreaming, mental confusion, staring blankly and hypoactivity. In the present study, we evaluated 5 common variants (rs6265, rs3746544, rs1051312, rs133946 and rs133945) located in 3 candidate genes ( BDNF ,  SNAP25  and  SYN III ) that are known to take part in synaptic plasticity and neurotransmitter transmission. We tested the effects of these variants on neuropsychological findings assessed by a computer-based neuropsychological test battery in children with inattention symptoms (SCT and/or ADHD). BDNF (rs6265), SNAP25 (rs3746544 and rs1051312) and SYN III (rs133946 and rs133945) polymorphisms were associated with variable cognitive measures.  BDNF  gene (rs6265) polymorphism Met allele carriers and  SNAP25  gene (rs3746544) T allele carriers had an association with the attention domain.  SNAP25  gene (rs1051312) C allele carriers were only associated with reaction time scores. Cognitive flexibility, which is one of the key components of executive function evaluation and shifting attention test scores were associated with  BDNF  (rs6265) Met allele and  SYN III  (rs133946) gene G allele.  SYN III  (rs133945) gene C allele carriers had an association with verbal memory correct hit scores. As a conclusion,  BDNF ,  SNAP25  and  SYN III  genes were associated with specific neurocognitive outcomes in children with inattention symptoms. It is important to note that exploring genotyping effects on neurocognitive functions instead of a heterogeneous psychiatric diagnosis can improve our understanding of psychopathologies.

nordic journal of psychiatry

Investigation of possible associations of the  BDNF, SNAP-25  and  SYN III  genes with the neurocognitive measures:  BDNF  and  SNAP-25  genes might be involved in attention domain,  SYN III  gene in executive function