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Marine algae’s, owing to diverse range of secondary metabolites, opening up the new avenues in new drug development and can be used efficiently in anticancer research. Two seaweeds  Gracilaria foliifera  and  Turbinaria conoides  are subjected to phytochemical investigation by HR-LCMS and NMR which confirms presence of different bioactive compounds. The cytotoxicity of the dichloromethane (DCM) fraction of  Gracilaria foliifera  and  Turbinaria conoides  was determined using an  in vitro  methyl thiazolyl tetrazolium (MTT) test and showed considerable dose-dependent cytotoxicity on tumour cell lines. In MCF7,  Gracilaria foliifera  had an IC 50  of 100 μg/ml, while  Turbinaria conoides  had an IC 50  of 200 μg/ml and both the DCM fraction had IC 50  values of 100 μg/ml in the A549 cell line. MTT assay for anticancer activity suggest that  Gracilaria foliifera  has potent anticancer activity in both breast and lung cell lines, while the DCM fraction of  Turbinaria conoides  has potent activity in lung cell lines and moderate activity in breast cell lines. The anticancer effects of the discovered drugs targeting the most prevalent enzymes VEGFR and AXL tyrosine kinases were confirmed using a computational technique. We believe that residues from VEGFR, like Lys868, Asn923, Asp1046, and Phe1047 and Asp690 from Axl kinase may have contributed to the plausible anti-cancer benefit seen in this study. Communicated by Ramaswamy H. Sarma

journal of biomolecular structure and dynamics

High-resolution liquid chromatography and mass spectrometry (HR-LCMS) assisted phytochemical profiling and an assessment of anticancer activities of  Gracilaria foliifera  and  Turbinaria conoides  using  in vitro  and molecular docking analysis