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Heritiera fomes  is a mangrove plant with a rich history of ethnomedicinal usage against chronic inflammation. Biochemical analyses of  H. fomes  have exposed a plethora of bioactive phytochemicals that contribute to this therapeutic effect by perturbing enzymes of a complex inflammatory network mediated by arachidonic acid (AA) metabolism. This study is the first instance of utilizing cheminformatic approaches to elucidate a molecular linkage between these phytochemical interventions and the multi-enzyme AA metabolic network regulation. Analysis of the simulations reflects  H. fomes  as a functional reservoir of multiple safe and potent natural anti-inflammatory compounds. The investigation suggests two phytocompounds extracted from the plant: a sesquiterpene lactone and a flavone glycoside, as candidate inhibitors of multiple catalytic checkpoints of the inflammatory network. The outcomes of this research act as a primary guideline for future laboratory and clinical testing of anti-inflammatory potentials of  H. fomes  as an exploitable source of safe and potent drug-like molecules. Communicated by Ramaswamy H. Sarma

Predicting multi-enzyme inhibition in the arachidonic acid metabolic network by Heritiera fomes extracts