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The binding of tRNA to aminobenzoic acid derivatives DAB-0 ( N' -[4-(2,5-dioxo-pyrrolidin-1-yl)-benzoyl]-hydrazine carboxylic acid  tert -butyl ester) and DAB-1 ( N' -[4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-benzoyl]-hydrazine carboxylic acid  tert -butyl ester) was investigated in aqueous solution at physiological pH. Thermodynamic parameters Δ H0  −4.8 to −4.30 (kJ mol −1 ), Δ S0  24.20 to 22 (J mol −1 K –1 ) and Δ G0  −12 to −11.40 (kJ mol −1 ) showed that DAB-0 and DAB-1 readily bind tRNA  via  ionic interactions with DAB-1 forming stronger tRNA adducts. Similar binding sites to A-T and G-C bases were located with DAB-0 and DAB-1. The binding efficacy ranged from 40% to 50%. No alteration of tRNA conformation was detected upon drug complexation. Communicated by Ramaswamy H. Sarma

Locating the binding sites of two aminobenzoic acid derivatives on tRNA: drug binding efficacy and RNA structure