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CYP3A4  and  CYP3A5  are biologically potential genes responsible for prostate cancer. We aimed to analyse the expression and association of  CYP3A4  and  CYP3A5  genes in prostate cancer. Web-based bioinformatics tools were used to assess the association of  CYP3A4  and  CYP3A5  genes with prostate cancer risks. A case-control study of 210 prostate cancer cases and 207 controls was also approved to determine the allelic variants of the  CYP3A4  gene- rs2740574 ( CYP3A4*1B ) and the variant of  CYP3A5  gene-rs776746 ( CYP3A5*3 ) using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The risk of prostate cancer was estimated as odds ratio (OR) and 95% confidence interval (CI) using unrestricted logistic regression models. Our  in silico  data confirmed that both  CYP3A4  and  CYP3A5  genes are significantly associated with higher prostate cancer risks. In the case of  CYP3A4*1B  polymorphism, the heterozygote (*1 A/*1B), mutant (*1B/*1B), and combined heterozygote plus mutant (*1A/*1B+*1B/*1B) genotypes showed 3.52-fold, 3.90-fold, and 3.67-fold increased risk of prostate cancer, respectively. In the case of  CYP3A5*3  polymorphism, the heterozygote (*1/*3), mutant (*3/*3), and combined (*1/*3+*3/*3) genotypes were found to be significantly associated with 5.11-, 5.49-, and 5.28-fold greater risk of prostate cancer, respectively. Our results indicate that  CYP3A4*1B  and  CYP3A5*3  are significantly associated with increased prostate cancer risk.

Genetic association in CYP3A4 and CYP3A5 genes elevate the risk of prostate cancer