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The aim of this study was preparation of a self-emulsifying drug delivery system (SEEDS) containing metformin hydrochloride. Hydrophobic ion paired complexes were prepared by electrostatic interaction between metformin and sodium lauryl sulphate (SLS). The nanodroplets were optimised using two-level full factorial methodology and their morphology were examined.  In vitro  release of metformin from SEDDS was evaluated in simulated gastric and intestinal fluids. Finally, the ex -vivo  efficacy of the optimised formulation in enhancing the intestinal permeability of metformin was evaluated using non-everted intestinal sac. The data revealed that in weight ratio 1:4(metformin: SLS), the highest recovery was achieved. The physico-chemical properties of the optimised nano-droplets including size, polydispersity index (PdI), zeta potential, and loading efficiency (%) were 192.33 ± 9.9 nm, 0.275 ± 0.051; −1.52 mV, and 93.75 ± 0.77% (w/w), respectively. The data obtained from the intestinal transport study demonstrated that SEDDS can significantly enhance the oral permeability of the compound.

journal of microencapsulation

Preparation and characterisation of self-emulsifying drug delivery system (SEDDS) for enhancing oral bioavailability of metformin hydrochloride using hydrophobic ion pairing complexation