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It has been demonstrated that infertility can affect quality of life (QoL) in infertile couples. Resilience is considered a protective factor against the distress caused by infertility and the quality of life status. There is a new definition for Fertility Quality of Life that evaluates particularly the impact of infertility on various aspects of life. In this couple-based study, the main objective was investigating the quality of life based on the gender and resilience of infertile couples. Measurement tools were three questionnaires including a demographic one, a quality of life of infertile couples questionnaire and the Connor–Davidson Resilience Scale. Data analysis was done through paired  t -test and linear multiple regressions test. Overall the difference of mean score for QoL is statistically significant ( P  &gt; 0.001) between men and women (69.48% vs 58.87%), which means that QoL status was positive in men and neutral in women. In addition, the mean score of male resilience was more than female resilience ( P  = 0.009). The results showed there was a significant and positive correlation between the QoL status and resilience score ( P  = 0.008,  r  = 0.13) ( P  &lt; 0.1), and resilience (β = 0.04 and  P  = 0.04) had a significant protective effect on the quality of life. Low resilience status in infertile couples is better to be considered as a risk factor compromising the quality of life and infertility consolers should keep in mind this issue and provide a comprehensive and holistic approach for a better outcome of infertility treatment. QoLICQ: Quality of Life in Infertile Couple Questionnaire; CD-RISC: Connor–Davidson Resilience Scale; IVF: in vitro fertilisation; ART: assisted reproductive technique; PTSD: posttraumatic stress disorder; IUI: intrauterine insemination; ICSI: intracytoplasmic sperm injection.

Resilience as the predictor of quality of life in the infertile couples as the most neglected and silent minorities