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Diospyros kaki  L.f. fruit and leaves are traditionally used for the treatment of hypertension, angina, internal hemorrhage, antithrombotic and anti-inflammatory effects.In the current study, the protective effects of ethyl acetate (Per-1),  n -butanol (Per-2), and aqueous (Per-3) fractions of  Diospyros kaki  leaves against carbon tetrachloride (CCl 4 ) induced nephrotoxicity in Swiss albino rats were tested. Animal were divided into nine groups; each group consists of six animals. The groups were : group I was untreated and kept as control, group II was treated with CCl 4  only, group III (silymarin with CCl 4 ); group IV (Per-1 100 mg/kg with CCl 4 );group V (Per-1 200 mg/kg with CCl 4 ); group VI (Per-2 100 mg/kg with CCl 4 ); group VII (Per-2 200 mg/kg with CCl 4 ); group VIII (Per-3 100 mg/kg with CCl 4 ); and group IX (Per-3 200 mg/kg with CCl 4 ). Silymarin was used as standard drug. All tested fractions were found active (except Per-1 at low dose of 100 mg/kg) with significant value ( p  &lt; 0.001) compared to CCl 4  only group. Serum creatinine, malondialdehyde (MDA), and uric acid were significantly ( p  &lt; 0.001) lowered in group VII–IX as compared to CCl 4  only group. Similarly, total protein (TP) and non-protein sulfhydryls(NP-SH) level in kidney tissues were significantly ( p  &lt; 0.001) elevated in the same groups compared to CCl 4  only group. Further to check the cardio-protective potential, biochemical parameters such as LDH, creatine kinase, TP, MDA, and NP-SH levels in myocardial tissues were also estimated.These findings confirmed that the n-butanol and aqueous fractions are active and recommended for further bioactive phytoconstituents screening. Repeated column chromatography on silica gel G and sephadex-LH-20 of the active n-butanol fraction, four flavonoids were isolated. Based on the spectroscopic NMR data, compounds were identified as kaempferol ( 1 ), quercetin ( 2 ), astragalin ( 3) , and rutin ( 4 ).

Nephroprotective effect of persimmon leaves ( Diospyros kaki L.f.) against CCl 4 -induced renal toxicity in Swiss Albino rats