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Endophytic fungi are promising sources of bioactive substances; however, their secondary metabolites are toxic to plants, animals, and humans. This study aimed toevaluate the toxic, cytotoxic, mutagenic and oxidant/antioxidant activities of acetonitrile extract (AEPc), citrinin (CIT) and dicitrinin-A (DIC-A) of  Penicillium citrinum . For this, the test substances at 0.5; 1.0; 1.5 and 2 μg/mLwere exposed for 24 and 48 h in  Artemia salina , and 48 h in  Allium cepa  test systems. The oxidant/antioxidant test was evaluated in pre-, co- and post-treatment with the stressor hydrogen peroxide (H 2 O 2 ) in  Saccharomyces cerevisiae . The results suggest that the AEPc, CIT and DIC-A at 0.5; 1.0; 1.5 and 2 μg/mL showed toxicity in  A. saline , with LC 50  (24 h) of 2.03 μg/mL, 1.71 μg/mL and 2.29 μg/mL, and LC 50  (48 h) of 0.51 μg/mL, 0.54 μg/mL and 0.54 μg/mL, respectively.In  A. cepa , the test substances also exerted cytotoxic and mutagenic effects. The AEPc, CIT and DIC-A at lower concentrations modulated the damage induced by H 2 O 2  in the proficient and mutant strains of  S. cerevisiae  for cytoplasmic and mitochondrial superoxide dismutase. Moreover, the AEPc at 2 μg/mL and CIT at the two highest concentrations did not affect the H 2 O 2 -induced DNA damage in the test strains. In conclusion, AEPc, CIT and DIC-A of  P. citrinum  may exert their toxic, cytotoxic and mutagenic effects in the test systems possibly through oxidative stress induction pathway.

Cytogenotoxic evaluation of the acetonitrile extract, citrinin and dicitrinin-A from Penicillium citrinum