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In recent years, herbal tea consumption becomes popular because of the potential health benefits and attractive flavors. However, there is also a growing concern that herbal supplements contribute to the drug-drug/drug-herb interactions and hepatotoxicity. In this study, FL83B mouse hepatocytes were used as an  in vitro  mode of hepatotoxicity induced by free fatty acids, including palmitic acid (PA) and oleic acid (OA), ethanol, and acetaminophen. Herbal tea extracts were obtained from eight common herbal plants, including  Verbena officinalis  L.,  Hyssopus officinalis  L.,  Salvia officinalis  L.,  Urtica dioica  L.,  Hemerocallis fulva  (L.) L.,  Citrus maxima  (Burm.) Merr.,  Citrus limon  (L.) Osbeck, and  Ficus formosana  Maxim. MTT assay was used to evaluate the impact of these herbal tea extracts on hepatoxocitity. We found that these herbal tea extracts  per se  did not exhibit hepatotoxicity, and had no effect on OA-induced hepatotoxicity. However, extracts from  Verbena officinalis  L.,  Hyssopus officinalis  L.,  Salvia officinalis  L., and  Hemerocallis fulva  (L.) L. exhibited protective effect against PA-induced hepatotoxicity. In addition, herbal tea extracts from  Verbena officinalis  L.,  Hyssopus officinalis  L.,  Salvia officinalis  L.,  Urtica dioica  L.,  Hemerocallis fulva  (L.) L., and  Ficus formosana  Maxim. exhibited protective effect against acetaminophen-induced hepatotoxicity. Interestingly, all these herbal tea extracts enhanced ethanol-induced hepatotoxicity. Our results suggest that herbal tea extracts have differential effects on different modes of hepatotoxicity.

Differential effect of herbal tea extracts on free fatty acids-, ethanol- and acetaminophen-induced hepatotoxicity in FL83B hepatocytes