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The present study was designed to determine protective effects of  Coleus forskohlii  hydroalcoholic leaf-extract along with its fractions against fructose-induced cataract rat model. The  Coleus forskolii  leaf extract was subjected to silica gel column chromatography and fractions were collected. A major high yielding fraction of the leaf extract, designated as fraction B6 was pharmacologically evaluated in Sprague Dawley albino rats at three doses 0.1, 1 and 10 mg/kg respectively. Compound B2; isolated from B6 fraction, identified as ‘gallic acid’ was also pharmacologically evaluated at three different doses. Cataract was induced by concurrent administration of fructose solution (10% w/v, per oral, dissolved in drinking water) for eight consecutive weeks. Mean arterial pressure, blood glucose level and lenticular opacity were determined. At the end of eight weeks,  C. forskohlii  leaf extract fraction and gallic acid reduced mean arterial pressure and glucose level in a dose dependent manner. In addition,  C. forskohlii  led to significant restoration of lens antioxidants enzyme level and reduced cataract formation in rats. These results showed the concentration dependent protective effect by  C. forskohlii  leaf extract against cataract formation due to restoration of oxidative stress markers.

Protective effect of Coleus forskohlii leaf-extract compound on progression of cataract against Fructose-Induced experimental cataract in rats