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Sir, Hyperkeratosis of the nipple and the areola (HNA) is a rare, benign condition characterized by asymptomatic hyperkeratosis and hyperpigmentation affecting the nipples and/or the areolae mammae (1 – 3). It may be idiopathic or associated with diseases such as ichthyosis, acanthosis nigricans, Darier’s disease or endocrinopathies. A few cases have also been reported related to internal malignancies, cutaneous T-cell lymphoma, or use of drugs (oestrogen and spironolactone) (4 – 7). We report here a case of HNA that developed during chronic cutaneous graft versus host disease (GVHD) following allogeneic peripheral blood stem cell transplantation.

Hyperkeratosis of the Nipple Associated with Chronic Graft versus Host Disease after Allogeneic Haematopoietic Cell Transplantation