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The CTD, which is unique to pol II, consists of a tandem array of a heptapeptide repeat with the consensus sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser. The mammalian pol II large subunit has 52 tandem repeats, whereas the Saccharomyces cerevisiae subunit has 27 copies. The IIA and IIO forms of pol II are interconvertible and functionally distinct. In vivo, …

Origins of mRNA identity: Capping enzymes bind to the phosphorylated C-terminal domain of RNA polymerase II