Open Access(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer.
Author(s) -
Jean C. Zenklusen,
Ivan Bièche,
Rosette Lidereau,
Claudio J. Conti
Publication year - 1994
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.91.25.12155
Subject(s) - loss of heterozygosity , biology , microsatellite , tumor suppressor gene , suppressor , genetics , chromosome , gene , breast cancer , cancer research , cancer , carcinogenesis , allele
Loss of heterozygosity in human chromosome 7q was studied to determine the location of a putative tumor suppressor gene. Twenty-six of 31 cases studied presented loss of heterozygosity at one or more loci on chromosome 7q. Eighty-three percent loss of heterozygosity (in 11 informative cases) was detected by using the (C-A)n microsatellite repeat marker D7S522 at 7q31.1-7q31.2. These results suggest that a tumor suppressor gene relevant to the development of breast cancer is present in the 7q31.1-7q31.2 region, confirming our previous evidence for a tumor suppressor gene in this chromosome and frequent deletions of the long arm in human primary breast cancers.