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The reactivities of N-iodosuccinimide and iodine with various goitrogenic compounds were studied with dimethylsulfoxide through which nitrogen had been bubbled as a solvent. Although iodine does not react with all of the compounds, N-iodosuccinimide does react with all of them. N-Iodosuccinimide may, therefore, serve as an interesting model for the "active iodine" of the thyroid.

The Reaction of N -Iodosuccinimide with the Goitrogens: A Model for the Active Iodine of the Thyroid Gland