Open AccessAnti-Antibody Activity of a Monoclonal Macroglobulin
Author(s) -
Noel L. Warner,
Malcolm MacKenzie,
H. Hugh Fudenberg
Publication year - 1971
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.68.11.2846
Subject(s) - monoclonal antibody , macroglobulinemia , macroglobulin , antibody , monoclonal , antigen , immunoglobulin m , immunology , chemistry , microbiology and biotechnology , waldenstrom macroglobulinemia , immunoglobulin g , biology , multiple myeloma , lymphoma
A monoclonal macroglobulin from a patient with Waldenström macroglobulinemia has been shown to have antiglobulin activity of a new type, namely, that of a true anti-antibody. The protein reacts with human, primate, and rabbit IgM and IgG, only when the target immunoglobulin is complexed to an antigen. The implications of the general findings of antiglobulin activity of monoclonal proteins is discussed in relation to the possible etiology of the disease.