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Some speculations on the origin and evolution of NC genes have been presented elsewhere."1 Summary.-Evidence has been presented of recombination in Chlamydomonas involving two nonchromosomal genes. The two are unlinked, but each exhibits intragenic recombination between mutant alleles, giving rise to wild-type recombinants. In one of them, the acetate gene, reciprocal recombinants containing both of the parental mutant sites have also been detected. The results are interpreted as evidence of the nucleic acid composition of these nonchromosomal genes.

Transcholesterin, a cholesterol-binding globulin: serological demonstration of a specific interaction between cholesterol and serum globulin.