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* This work was' supported in part by funds received from the Eugene Higgins Trust through Harvard University and from the Life Insurance Medical Research Fund. t The following abbreviations are used: DPN, DPNH, oxidized and reduced diphosphopyridine nucleotide respectively; TPN, TPNH, oxidized and reduced triphosphopyridine nucleotide respectively. t Recent experiments have clearly indicated that thyroxine does inhibit the transhydrogenase reaction. It has also been possible to show that the naphthoquinone SN5949 does not exert its inhibitory effect by a direct actionIupon the transhydrogenase enzyme. ' E. G. Ball, in A Symposium on Respiratory Enzymes (Madison: University of Wisconsin Press, 1942), p. 38. 2 S. P. Colowick, N. 0. Kaplan, E. F. Neufeld, and M. M. Ciotti, J. Biol. Chem., 195, 95, 1952.

MEIOTROPHIC MUTANTS OF Pasteurella Pestis AND THEIR USE IN THE ELUCIDATION OF NUTRITIONAL REQUIREMENTS