English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Our study demonstrates that CD34+ cells generated from human induced pluripotent stem cells (iPSCs) genetically engineered to confer resistance to HIV have engraftment capabilities if they are derived in vivo but not in vitro. We used iPSCs from HIV-infected patients under antiretroviral therapy to form teratomas in immunodeficient mice and isolated CD34+ cells from these teratomas. We showed not only that these CD34+ cells could engraft in recipient mice but also that their cell progeny found in the mouse peripheral blood was resistant to HIV infection. These findings confirm the potential for evaluating in an animal model the clinical development of cure therapies using genetically modified autologous iPSCs from patients with HIV.

Genetically edited CD34 + cells derived from human iPS cells in vivo but not in vitro engraft and differentiate into HIV-resistant cells

Genetically edited CD34 ⁺ cells derived from human iPS cells in vivo but not in vitro engraft and differentiate into HIV-resistant cells