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Significance In tumors, tissue oxygen heterogeneity leading to the appearance of hypoxic regions is linked to poor prognosis and reduces the efficiency of therapeutic treatment. Following previous reports that vessel compression, caused by the tumor, leads to tumor tissue oxygen heterogeneity, we formulate a computational model to investigate the mechanism whereby vessel compression affects tissue oxygenation. Our results show that compressed vessels lead to an abnormal partitioning of red blood cells at vascular bifurcations and therefore heterogeneity in oxygen transport to tissue. This work uncovers a biomechanical causal link between vessel compression and tumor tissue oxygen heterogeneity, furthering our understanding of the tumor microenvironment and contributing to an emergent theory of biotransport in tumors that can underpin future therapeutic approaches.

Compressed vessels bias red blood cell partitioning at bifurcations in a hematocrit-dependent manner: Implications in tumor blood flow