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Significance A major question in tissue biology is how cells manage to maintain stable cell–cell adhesion using the intrinsically weak homophilic bonds of cadherin adhesion molecules. One suggestion is that cells cluster cadherins into large puncta to promote strong adhesion. However, we now show that puncta are not clusters of cadherins but rather interdigitated protruding microspikes. Actin polymerization–dependent protrusive activity generates the interdigitated fingers that help hold the cells together by increasing the membrane surface area available for cadherin–cadherin molecular interactions and by generating a rough, interlocking topography to impede relative movement between cells. The latter, analogous to friction, may offer a physical means of adhesion to compliment the chemical adhesion afforded by cadherin–cadherin homophilic binding.

Cadherin puncta are interdigitated dynamic actin protrusions necessary for stable cadherin adhesion