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Significance The standard genetic code (SGC) is common to all sufficiently explored Earth biota, suggesting a common origin for protein biosynthesis in every known organism. The ancient events leading to this near-universal biological characteristic are manifestly of scientific importance. The accompanying text presents a detailed pathway for formation of the SGC, as well as a method for identifying essential origin events. Significantly, the SGC can evolve using only well-characterized chemical, biochemical, and physical mechanisms, paralleling other known evolutionary transitions.

Fitting the standard genetic code into its triplet table