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Significance Brain function relies on tasks executed by different types of neurons generated via diverse mechanisms. Combining a series of genetic, cellular, and behavioral approaches, we identify a two-step glia-to-neuron signal that regulates how neurons are produced in theDrosophila mushroom body, a key learning center for animal behavior. This glial signal requires the action of an E3 ubiquitin ligase dSmurf that regulates the stability of two downstream effectors: the Hedgehog receptor Patched and the cell-adhesion molecule Fasciclin II. Our findings demonstrate the significance of glial cells in regulating neuron production, hence the brain function and animal behavior.

Glia-derived temporal signals orchestrate neurogenesis in the Drosophila mushroom body