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Significance Proper resolution of inflammation is essential for restoration of homeostasis. Macrophages are particularly important for this process and dynamically change their functional phenotypes during the transition from inflammatory activation to resolution. we identify a long noncoding RNA,lncFAO , that promotes inflammation resolution. Deletion oflncFAO perturbed late suppression of inflammatory gene expression after LPS treatment and exacerbated endotoxic shock and skin wounds in vivo, which demonstrates thatlncFAO is integral to inflammation resolution in macrophages. Mechanistically,lncFAO directly interacts with the HADHB subunit of mitochondrial trifunctional protein and activates fatty acid oxidation. Our data indicate thatlncFAO is a mediator of metabolic reprogramming for resolution of inflammation in macrophages.

A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation