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Significance Numerous real-world motor skills require learning arbitrary relationships between actions and their consequences from scratch. However, little is understood about the neural signatures of de novo motor learning and associated individual variability. In a longitudinal fMRI experiment, where participants learned to control a cursor by moving fingers, we found a gradual transition of performance-related activity from the head to tail of the caudate nucleus. This finding reflects the flexible and stable reward representations in the head and tail, respectively. Additionally, intrinsic cortico-caudate connectivity predicted better learners with weaker head–prefrontal and stronger tail–sensorimotor interactions. The present study provides unprecedented insight into de novo motor learning, which may contribute to the understanding of motor-related disorders, and infant learning.

Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning