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Significance Aging is associated with a myriad of changes at all levels of organization of an organism. However, how it affects protein synthesis, a major metabolic activity of the cell, is unknown. We discovered deregulation of protein synthesis and ribosome biogenesis machinery specifically at the translational level with age. Moreover, ribosomes were depleted in the vicinity of start codons and increased near stop codons. These findings reveal systematic, multilevel deregulation in gene expression and protein synthesis, showing how this major cellular process declines with age.

Multifaceted deregulation of gene expression and protein synthesis with age