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Significance Astrogenesis occurs during sequential differentiation of neural stem cells. This is because astrocyte production is repressed in the early embryonic stage, but the reasons for this repression need to be comprehensively understood. External and internal signals must contribute to this phenomenon. The signal trigger requires two factors: the ligand and receptor. Which ligand in the niche is involved? Which receptor in the membrane of neural stem cells is involved? Here, we focus on a receptor named CD93, which is known for its immune functions. We reveal its function in the differentiation of neural stem cells independent of immunity. CD93 responds to MMRN2 to control the proper timing of astrogenesis. In conclusion, our study identifies a negative regulator in astrogenesis.

CD93 negatively regulates astrogenesis in response to MMRN2 through the transcriptional repressor ZFP503 in the developing brain