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Significance The mammalian placenta is a target for endocrine-disrupting chemicals, such as the widely prevalent plasticizer bisphenol A (BPA). Consumer unease with BPA has led to manufacture of substitutes, such as bisphenol S (BPS). Here, we used a multiomics approach to study effects of developmental exposure to BPA and BPS on midgestational mouse placenta. BPA and BPS caused almost identical changes in gene expression; similar morphological defects in the junctional zone, which forms the interface of the placenta with maternal endometrium; and marked alterations in placental content of neurotransmitters serotonin and dopamine. The results imply that in rodents there could be associated effects on the placental–fetal brain axis. We also conclude that BPS should be regarded as hazardous as BPA.

Bisphenol A and bisphenol S disruptions of the mouse placenta and potential effects on the placenta–brain axis