English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance There is concern for design of a safe vaccine for Zika virus because antibodies (Abs) elicited against Zika may also bind flaviviruses that share a similar envelope protein. If Abs elicited by a Zika vaccine bind, but do not effectively neutralize other flaviviruses, they may enhance virus entry into cells through the process of Ab-dependent enhancement of infection, potentially leading to more severe disease. By directly comparing how mature Zika-neutralizing Abs and their germline precursors bind different flaviviruses, we provide insight into the Ab maturation process and the molecular interactions important for strong, neutralizing binding to Zika versus weak, cross-reactive binding to other flaviviruses.

Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody