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Significance The outer membrane of gram-negative bacteria presents a formidable barrier for the entry of antibiotics and is a significant contributor to the intrinsic drug resistance of these organisms. The highly conserved Tol-Pal complex has long been known to be required for the proper biogenesis of this surface layer, with its main function commonly believed to be promoting outer membrane constriction during cell division. In this report, we show that the machinery is needed to promote the cleavage of cell wall glycans at the division site to promote daughter cell separation. Thus, the Tol-Pal system may play multiple roles during cell division to ensure that outer membrane invagination and cell wall processing are properly coordinated.

The Tol-Pal system is required for peptidoglycan-cleaving enzymes to complete bacterial cell division