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Significance The key molecular mechanisms underlying the etiology of bipolar disorder (BD) have remained enigmatic. As BD patients often show comorbidity with insulin/glucose metabolic syndrome, we hypothesized that the central and peripheral abnormalities might share some identical molecular mechanism. Through investigating the expression of insulin/synapse dual functioning genes in patient induced pluripotent stem cell-derived neurons and their effects on mouse behaviors, as well as testing the mRNA level in BD patient plasma samples, we demonstrated that Syt7 is likely a key factor involved in neuropsychiatric-like behaviors. Our work helps explain the molecular mechanism involved in the pathogenesis of BD.

Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice