English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance T cell coreceptors are often described as molecular switches that broadly regulate T cell activation by enhancing or repressing T cell receptor (TCR) signaling according to the immunological context. However, many coreceptors act more selectively by instructing or restricting specific T cell responses. The molecular mechanisms by which these subtle regulations occur remain incompletely defined. In this study, we show that CD5 coreceptors engage a multimeric signaling complex, which synchronize positive and negative feedback on TCR signaling to limit the induction of inopportune regulatory T cells during immune response. Our findings suggest that rather than exclusively acting as stimulators or inhibitors of TCR signaling, coreceptors may coordinate antagonist TCR signals that act together to promote specific T cell responses.

CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens