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Significance Monocytes circulate in the blood and are involved in host defense, inflammation, neurodegeneration, and autoimmune disease. How and where these cells enter the brain during disease remains poorly understood. We analyzed monocyte recruitment to the brain during infection withToxoplasma gondii , a global foodborne parasite that establishes chronic infection in the CNS. By using 2-photon imaging through cranial windows, we dynamically tracked fluorescent monocytes at the blood–brain barrier from the acute to chronic stage of infection in mice. Whole-brain imaging revealed distinct localization patterns of monocytes in specific brain regions and near sites of parasite infection, providing a global 3D analysis of monocytes in the brain and indicating portals of entry for immune cells to the CNS during infection.

Imaging the dynamic recruitment of monocytes to the blood–brain barrier and specific brain regions duringToxoplasma gondiiinfection