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Significance DNA helicases are motor proteins that operate on nucleic acids during DNA replication, recombination, and repair. Repetitive translocation on and unwinding of nucleic acids is an emerging property of multiple helicases. How this repetitive enzymatic activity may be used for function remains unclear. For the 5′-3′ Pif1 family of helicases our data suggest a model in which a highly processive opening of short stretches of DNA is all that this class of nonreplicative helicases need to achieve when their function is coupled to DNA replication.

Branched unwinding mechanism of the Pif1 family of DNA helicases