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Significance NF1 is a monogenic disorder caused by mutations in theNF1 gene. While it affects multiple organs and tissues, how brain symptoms arise has been complicated to uncover. Since brain glial and inhibitory neuron cells have been implicated in NF1, we conditionally deleted the mouseNf1 gene in progenitors that give rise to both of these cell types. We found that glial cells were impacted when both copies ofNf1 were deleted, while properties of a specific group of inhibitory neurons were altered when either one or both copies ofNf1 were deleted. These data demonstrate phenotypes that may contribute to NF1 and uncover roles for theNf1 gene in brain development.

Nf1 deletion results in depletion of the Lhx6 transcription factor and a specific loss of parvalbumin + cortical interneurons

Nf1 deletion results in depletion of the Lhx6 transcription factor and a specific loss of parvalbumin ⁺ cortical interneurons