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Significance EAE typically presents with hind-limb paralysis and is associated with severe T cell-mediated inflammation and axon injury throughout the spinal cord and parts of the brain. Because axon loss is so rapid in this model, it is difficult to intervene for the purpose of evaluating neuroprotective therapies. Here we describe a mild form of EAE that does not even meet the threshold for scoring on traditional EAE scales, yet with age results in devastating neurodegenerative changes in the spinal cord, including grey matter atrophy, neuron loss, and synapse degradation. These observations underscore the utility of T cell receptor transgenic mice to study the effect of natural aging on CNS autoimmunity and neurodegeneration.

Aged hind-limb clasping experimental autoimmune encephalomyelitis models aspects of the neurodegenerative process seen in multiple sclerosis