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Significance We developed and validated an approach for long-term in vivo monitoring of sodium levels in the bloodstream using erythrocyte camouflaging of microsensors combined with noninvasive optical readout of the microsensors while in circulation. Sodium imbalance is an important indicator for toxicity during lithium treatment for bipolar disorder. Lithium treatment has a toxic threshold close to its narrow therapeutic window, which drives the need for long-term continuous monitoring to prevent adverse effects. Our study describes an approach to drug monitoring by using biomimicry and optical reader technology, with wide potential impact toward treatment regimens for bipolar disorder and other conditions.

Real-time particle-by-particle detection of erythrocyte-camouflaged microsensor with extended circulation time in the bloodstream