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Significance Serotonergic neurons in the dorsal raphe nucleus have been implicated in olfactory learning and processing of olfactory information. While the piriform cortex is an important olfactory center critically involved in olfactory learning and coding of odor information and receives intensive serotonergic innervation, how the piriform cortex is modulated by the serotonergic inputs is largely unknown. We investigate this issue in vitro and in vivo. Our findings provide direct evidence for serotonergic modulation of neural activity in the anterior piriform cortex, identify the mechanism for this modulation, and shed light on its potential role. This study is important to understanding how centrifugal inputs modulate processing of olfactory information and the role of the serotonergic system in the brain as a whole.

Serotonergic afferents from the dorsal raphe decrease the excitability of pyramidal neurons in the anterior piriform cortex