English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Significance Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting 2 to 3% of the general population and leading to significant morbidity and mortality. Genome-wide association studies identified the 4q25 AF risk locus, a region that forms long-range interactions with the promoter ofPITX2 , which encodes a critical transcriptional regulator of cardiac development. Using a zebrafishpitx2c loss-of-function model, we find that larval and adult zebrafish phenocopy many hallmarks of human AF. Our data further indicate that the pathogenesis of arrhythmia and AF-like phenotypes inpitx2c mutants is driven by developmental perturbations to sarcomere organization and metabolic pathways. We also find that antioxidant treatment reduces the incidence and severity of cardiac arrhythmia, suggesting avenues for therapeutic strategies.

Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model