English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Barrier-to-autointegration factor (BAF), a highly conserved small protein in metazoans, plays multiple functions during the cell cycle; however, the regulation of BAF function is largely unclear. Here we find that the SUMOylation and de-SUMOylation cycle of BAF regulates these functions. We reveal that BAF is SUMOylated at K6, and that de-SUMOylation at this site is catalyzed by SENP1 and SENP2. SUMOylation of BAF regulates binding to lamin A/C, which is essential for nuclear retention of BAF. SUMOylation of BAF also regulates the interaction of BAF with nuclear DNA. De-SUMOylation facilitates cytoplasmic retention of BAF and loss of nuclear function. Non-SUMOylatable BAF is not efficiently retained in the nucleus, leading to structurally abnormal nuclear formation and DNA replication failure.

K6-linked SUMOylation of BAF regulates nuclear integrity and DNA replication in mammalian cells