English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis of premature infants and is a leading cause of death in these patients. It is an orphan disease with no specific treatment. In this study, we investigated the mechanisms of NEC-related thrombocytopenia, a characteristic feature of this disease. We tested the hypothesis that platelet activation and depletion occur during NEC once mucosal disruption is well established and is secondary to bacterial translocation across the damaged mucosa. Surprisingly, platelet activation turned out to be an early thrombin-mediated pathogenetic event during NEC-like injury. We show that a targeted nanomedicine approach to inhibit thrombin can attenuate NEC-like injury. If confirmed in clinical studies, this would be a specific treatment for NEC.

Targeted inhibition of thrombin attenuates murine neonatal necrotizing enterocolitis