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Significance Jasmonates (JAs) are essential phytohormones regulating a myriad of developmental and defensive responses in plants. MYC2, MYC3, and MYC4 are key transcriptional activators of JA-mediated gene expression and have become relevant signaling hubs. Repression of MYC activity is necessary for resetting JA signaling and to avoid harmful runaway responses, which contribute to plant fitness. Here, we identified a mechanism to reduce MYC protein levels by E3 ubiquitin ligases based on Cullin3 and BPM proteins as substrate adaptors (CUL3BPM ). BPM3 stability is enhanced by JA, establishing a negative feedback regulatory loop to control MYC levels and activity. Our results uncover a new layer of JA-pathway regulation that terminates MYC activity by CUL3BPM -mediated degradation of MYC TFs.

CUL3 BPM E3 ubiquitin ligases regulate MYC2, MYC3, and MYC4 stability and JA responses

CUL3 ^BPM E3 ubiquitin ligases regulate MYC2, MYC3, and MYC4 stability and JA responses