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Significance Chromatin modifications are broadly believed to influence gene expression, and are thought to transmit epigenetic memory of gene expression across mitotic generations. The best available evidence about the fate of nucleosomes during DNA replication is at odds with this intuition. This work studies the biochemistry of chromatin replication in living cells, and demonstrates that nucleosomes can, in fact, transmit epigenetic memory. Furthermore, contrary to published models, nucleosomes were not observed to translocate locally during transcription. This work motivates a substantial reevaluation of published biochemical data about chromatin replication and transcription.

The nucleosome core particle remembers its position through DNA replication and RNA transcription