English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Significance Alcohol drinking is a widespread habit in modern society and can cause deleterious metabolic consequences. Recent studies have uncovered the interplay between nutrition, metabolism, and circadian rhythms. Here we explore the effects of alcohol consumption on circadian physiology. We employed unbiased high-throughput proteomics, acetylomics, and circadian transcriptomics to provide a comprehensive analysis of liver metabolism and compared the outcomes of acute and chronic alcohol consumption. We reveal that distinct patterns of alcohol consumption differentially reprogram circadian gene expression in the liver. Particularly, rewiring of circadian SREBP pathways impacts subcellular partitioning of protein acetylation through acetyl-CoA metabolism. These findings contribute to understanding the underlying mechanism of alcoholic liver disease and establishing circadian therapeutic targets and strategies.

Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake